Florian Brand

Over two weeks, Prime Agent orchestrated a swarm of over 2,000 agents to rewrite itself in Rust.

With 10,000+ sandboxes, 200B+ GLM-5.3 tokens, and 16,000 agent-to-agent messages, this was our largest test yet of Prime Agent’s multi-agent capabilities and our infrastructure powering these agent swarms.

Prime Agent now reaches usable input ~13× faster and uses 83% less startup memory than before.

Introducing Microsoft-Decision-1, our new model for fast decision-making.

It delivers top performance on structured decision tasks, outperforming both LLMs and other decision models in latency and quality.

We’re already testing it across Microsoft for everything from incident response and quality control to scientific discovery.

Today we're launching the Alzheimer's Translation Challenge, a global AI competition to discover new therapeutic hypotheses for Alzheimer's disease.

At its core is a new 150M cell atlas of neurons, astrocytes, and microglia across different genetic backgrounds under combinatorial perturbations, with multi-modal readouts.

The data will be made available through the AD workbench, Hugging Face and Prima Mente's modeling platform.

The challenge is led by @PrimaMente and @AlzData in collaboration with @nvidia, @huggingface, @nebiusai, Talisman Therapeutics, @UltimaGenomics, @cellanome, @PrimeIntellect, @GoodfireAI, and @boltz_bio.

In 1906, Alois Alzheimer described a new disease of the brain. After 120 years of progress, we still don't fully understand what drives this disease. We want to change that.

Participants will use the dataset to build AI models, assessed through a series of evals from general benchmarks to more complex tasks.

Top teams will be shortlisted, and their experimental hypotheses tested in Prima Mente's wet lab. Teams win when their hypotheses demonstrate the predicted molecular and functional effect.

welcome to the 9th annual @stateofai report!

ai building better ai, world models, physical ai, geopolitics, cyber defense and 12-month predictions.

read it at stateof(dot)ai or watch my editor’s cut here.

a few of this year’s biggest findings follow:

As models become more capable, reward hacks become an increasingly serious problem.

During a controlled experiment, we found a novel reward hack in which agents are able to gain web access in offline sandboxes.

Let your app choose the right model, tool, or action in near real-time with Decisions API, now available to all developers in public beta.

The Decisions API makes decisions up to 10x faster than GPT-6 Luna through the Responses API.

Rare @huggingface L, @ClementDelangue

I’m tired of seeing gaunt celebs online and everyone around me being on reta

can I take a pill to get fat? maybe a leptin blocker??