Hani Goodarzi on X: “Then take the same cells out of the mouse and most of that falls apart…”

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Hani Goodarzi on X: “Then take the same cells out of the mouse and most of that falls apart…” | PeekX

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Hani Goodarzi

@genophoria

Oct 9

The outcome: redundant doesn’t mean interchangeable. In tumors, isodecoder dependencies alone can tell you the tissue of origin, and isoacceptor dependencies track codon usage (the more a codon is used, the more cells need the tRNA that reads it).

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Hani Goodarzi

@genophoria

Replying to @genophoria

Then take the same cells out of the mouse and most of that falls apart. In contrast amino acid synthetases barely care whether they’re in a tumor or a dish; tRNA dependencies very much do.

The dish-to-tumor shift is shared across lines though, and some tRNAs push it while others

Oct 9, 2026, 4:52 PM UTC

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