So we knocked down (CRISPRi) basically the entire cytoplasmic tRNA repertoire in 16 cancer cell lines from 7 tissues... and ran every screen twice: as tumors in mice and in a dish.
The outcome: redundant doesn’t mean interchangeable. In tumors, isodecoder dependencies alone can tell you the tissue of origin, and isoacceptor dependencies track codon usage (the more a codon is used, the more cells need the tRNA that reads it).