Hani Goodarzi on X: “So we knocked down (CRISPRi) basically the entire cytoplasmic tRNA rep…”

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Hani Goodarzi on X: “So we knocked down (CRISPRi) basically the entire cytoplasmic tRNA rep…” | PeekX

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Hani Goodarzi

@genophoria

Oct 9

The genetic code is fixed, but the machinery reading it isn’t. Hundreds of tRNA genes, multiple tRNAs per amino acid, multiple versions of the same anticodon. The usual story is that it’s all redundancy for robustness. We wanted to know if that’s really it. We have previously

biorxiv.orgThe adaptive architecture of tRNA dependencies across physiological tumor environments

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Hani Goodarzi

@genophoria

Replying to @genophoria

So we knocked down (CRISPRi) basically the entire cytoplasmic tRNA repertoire in 16 cancer cell lines from 7 tissues... and ran every screen twice: as tumors in mice and in a dish.

Oct 9, 2026, 4:52 PM UTC

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