Aditi Merchant on X: “We next applied Proto to more synthetic tasks where close natural anal…”

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Aditi Merchant

@aditimerch

Jun 23

To test generality, we first reimplemented five published campaigns in Proto: symmetric proteins, de novo monomers, CRISPR-Cas systems, antibody CDRs, and multi-kilobase chromatin designs. Despite varied models, design objectives, and optimizers, all were expressible in Proto.

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Aditi Merchant

@aditimerch

Replying to @aditimerch

We next applied Proto to more synthetic tasks where close natural analogs are less available. We designed introns with cell-line-specific splicing in human cells by inverting AlphaGenome and SpliceTransformer, using models built to predict splicing as constraints to design it.

Jun 23, 2026, 3:57 PM UTC

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