Science Magazine

A preclinical @scisignal analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to #oxphos curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions. scim.ag/4yJKeNV

In a new #ScienceReview, researchers highlight the emerging research surrounding the immune system’s role in preparing a mother’s body for pregnancy.

Learn more: scim.ag/3TC3BJB

Women are more likely than men to develop dementia, and not just because they tend to live longer.

One reason may be menopause, the time in midlife when sex hormones drop and menstruation stops—and which some researchers are coming to see as a stress test for the brain.

Learn more: scim.ag/47atALj @NewsfromScience

Wooden artifacts and imprints show a substantial role for Neanderthal woodworking in the Middle Paleolithic.

Learn more in @ScienceAdvances: scim.ag/476NcQA

Why do large dogs tend to live shorter lives than their smaller counterparts?

The answer may be written into their epigenome, according to a new study in Science. The findings reveal that larger and male dogs undergo accelerated molecular aging, with pronounced DNA methylation on the X chromosome and at transposable elements.

Learn more: scim.ag/3VZtl3f

We reported in @ScienceMagazine last week on a "self-capping" living supramolecular polymerization that yields chemically segmented, oppositely charged assemblies with precise lengths and collective molar mass reaching into the billion-dalton range.
science.org/doi/10.1126/sc…

Excited to share the Snyder-Mackler lab’s latest publication in @ScienceMagazine, highlighting research I’ve been highly involved in since joining the lab:
science.org/doi/10.1126/sc…

Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. @scisignal scim.ag/47DLyG8

Birds lay eggs in a diverse array of colors, patterns, sizes, and shapes.

After looking at nearly 50,000 eggs from more than 1400 bird species, researchers in Science found that egg shape is related to flight ability.

Learn more on #WorldEggDay: scim.ag/49ypeiX

In the murky, muddy puddles and jungle rivers across Suriname, a flat-backed frog lies in wait. Soon, it senses a small fish swimming by and pounces, swiping it into its tongueless mouth before engulfing it whole.

How does this creature, known as the Suriname toad, detect its prey? Its strange, star-shaped toes.

A new study shows the Suriname toad’s toes are highly tuned sensory organs that function somewhat like tactile eyeballs, enabling them to size up putative prey and see them without actually seeing them.

Learn more: scim.ag/4hp9S4l @NewsfromScience

"A claim is contestable when qualified researchers can reconstruct consequential choices from question to conclusion, inspect the evidence and assumptions that shaped them, compare plausible alternatives, and challenge decisions in ways that could change the result. This was true long before AI; what AI changes is where those choices are made," writes Christoph Trattner in a new #ScienceEditorial. scim.ag/4htUiV8

Researchers in @ScienceAdvances have developed a cross-national “speech clock” that can track biological aging and markers of dementia across a large and diverse sample of Latin American populations. scim.ag/47rTx99

Ancient sea-level changes provide new evidence that during the Jurassic and Cretaceous, Earth underwent episodes of rapid “true polar wander,” which occurs when the solid outer Earth shifts relative to its spin axis.

Learn more in Science: scim.ag/4hJJP6M

How does the body balance immune response and tissue damage during a #parasite infection?

A new @SciImmunology study in helminth-infected mice shows dermal #gdTcells that migrate to the lung activate immune pathways that protect tissues. scim.ag/4AMacSa

Do human longevity products provide meaningful clinical benefits?

Researchers in a new #SciencePolicyForum argue that longevity products claiming to prevent or reverse aging should follow established FDA approval pathways and be supported by rigorous evidence of effectiveness, and safety. scim.ag/4hsqEzx

In my latest Expert Voices column for @ScienceMagazine, I weigh in on this summer's - and this week's - AI for math news:

AI has solved many math problems, but it has not solved math | Science science.org/doi/10.1126/sc…

A person’s microbiome may help determine whether they develop a fever after receiving a vaccination, according to a new study in Science.

The findings suggest that the microbiome and potentially diet could one day be targeted to reduce vaccine-related inflammation without compromising the immune protection vaccines provide. scim.ag/4jRf4zo

New @ScienceMagazine
A breakthrough in understanding why do we get fever and an inflammation response to vaccines.
The gut microbiome chronic production of flagellin
Paves the way to potentially prevent these acute phase side-effects in the future
science.org/doi/10.1126/sc…

Why do small dogs live longer than large dog species, and what is the biologic basis of differences in lifespan and healthspan?
Epigenetics.
There's a lot in the methylation pattern of dogs to explain this @ScienceMagazine
science.org/doi/10.1126/sc…

Researchers address the settlement of Hawai‘i and Rapa Nui—by way of the Mangareva Islands—and the resulting concentration of certain alleles in those populations.

Learn more in this week’s issue of Science: scim.ag/3VCMt70